The Biocomplexity Institute and Initiative at theUniversity of Virginia integrates scientific research from genetic sequencing to policy analysis – to tackle the complex task of understanding massively interacting systems and predict solutions to issues impacting human health, well-being, and habitat. As pioneers in biocomplexity, we understand that interactions at the micro level can produce significant effects on the macro scale. We collaborate across many disciplines to discover connections between health, information networks, security and infrastructure. The foundation of our methodology lies in information biology; the synthesis of mathematics, computation, informatics, and biology. We approach complex problem solving by assembling teams of experts in a variety of fields to work together to create solutions that challenge the very fields in which the teams operate.