Sanford Research is a non-profit research organization that is a part of Sanford Health, the largest rural, not-for-profit health care system in the nation. Transformational gifts by Denny Sanford have propelled Sanford Research in its goal of becoming a world class research institution. Sanford Research has sought to establish a core of scientists that are studying disease at a fundamental level with the expectation that these current efforts will pay off in the future by advancing disease therapy and prevention.

 With a team of over 200 researchers, Sanford Research is comprised of eight groups that bridge bench, translational and clinical research including: Cancer Biology and Immunotherapies, Pediatrics and Rare Diseases, Diabetes, Cellular Therapies and Stem Cell Biology, Enabling Technology, Environmental Influences on Health and Disease, Genetics and Genomics, and Population Health.